Small molecules with novel therapeutic target

Dr. Ge Zhang's Lab has an interest in collaborating with molecular biologists for identifying potential molecular target, with structural biologists for analyzing structure of potential molecular target, and with bioinformatics scientist for modeling the potential targets and subsequent virtual screening in small molecular libraries or even performing de novo drug design

(Figure 5) (S Zhang et al. Clinical pharmacology & Therapeutics 2010) In silico discovery of small-molecule inhibitors targeting microRNAs; such inhibitors can be used as anticancer therapeutics.

Reference

  1. S Zhang, L Chen, EJ Jung and GA Calin. Targeting MicroRNAs With Small Molecules: From Dream to Reality. Clinical pharmacology & Therapeutics 2010; 87(6):754-8.